Biology, Free Full-Text
Por um escritor misterioso
Last updated 20 setembro 2024
In addition to representing a significant part of the natural background radiation exposure, α-particles are thought to be a powerful tool for targeted radiotherapy treatments. Understanding the molecular mechanisms of recognition, signaling, and repair of α-particle-induced DNA damage is not only important in assessing the risk associated with human exposure, but can also potentially help in identifying ways of improving the efficacy of radiation treatment. α-particles (He2+ ions), as well as other types of ionizing radiation, and can cause a wide variety of DNA lesions, including DNA double-strand breaks (DSBs). In mammalian cells, DNA DSBs can be repaired by two major pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). Here, we investigated their dynamics in mouse NIH-3T3 cells through the recruitment of key proteins, such as the KU heterodimer for NHEJ and RAD51 for HR upon localized α-particle irradiation. To deliver α-particles, we used the MIRCOM microbeam, which allows targeting of subnuclear structures with submicron accuracy. Using mouse NIH-3T3 cells, we found that the KU heterodimer is recruited much earlier at DNA damage sites marked by H2AX phosphorylation than RAD51. We also observed that the difference in the response of the KU complex and RAD51 is not only in terms of time, but also in function of the chromatin nature. The use of a microbeam such as MIRCOM, represents a powerful tool to study more precisely the cellular response to ionizing irradiation in a spatiotemporal fashion at the molecular level.
A piece of biology text annotated with multiple ontologies.
[Campbell, Neil A.] on . *FREE* shipping on qualifying offers. MasteringBiology w/MasterdingBiology Virtual Lab Full Suite SACC for
MasteringBiology w/MasterdingBiology Virtual Lab Full Suite SACC for Campbell Biology, Intl Ed
Biology Text Written Image & Photo (Free Trial)
20 lab report example biology - Free to Edit, Download & Print
Free Curriculum Vitae Example
SUSTech Jixian Zhai's group develops protoplasting-free full-length single-nucleus RNA profiling technology in plants - SUSTech · SCHOOL OF LIFE SCIENCES
Nature Reviews Molecular Cell Biology on X: From May cover Challenges and directions in studying cell–cell communication by #ExtracellularVesicles @DaveCarter1234 @guillaume_niel @VaderPieter Clayton Lambert & Raposo #EVsAreCool FREE pdf: https
SURFBIO project on LinkedIn: NEW FREE TRAINING⚠️ Are you a Master's or PhD student interested in…
Premium Vector Biology 3d text effect vector download
Listen Free to How Biology Works: The Facts Explained by Dk with a Free Trial.
A new spin on the Web Nature Structural & Molecular Biology
Red And Yellow Modern Work Biology Checklist - Venngage
ArchAlign: coordinate-free chromatin alignment reveals novel architectures, Genome Biology
A text-book of animal physiology, with introductory chapters on general biology and a full treatment of reproduction Physiology, Comparative. CATALOGUE OF MEDICAL WORKS. 37 POORE. Osteotomy and Osteoclasis, for the
Text Book of Biology, Part 1: Vertebrata by H. G. Wells
Recomendado para você
-
Smart TV Club APK for Android Download20 setembro 2024
-
Viruses, Free Full-Text20 setembro 2024
-
SAMSUNG 85 Class Q80B-Series QLED 4K Smart TV - QN85Q80BDFXZA20 setembro 2024
-
Serato ITCH 2.2.2, Scratch Live 2.4.3 & Video 1.120 setembro 2024
-
IJERPH, Free Full-Text20 setembro 2024
-
Structural Diversity of Copper(I) Cluster-Based Coordination Polymers with Pyrazine-2-thiol Ligand20 setembro 2024
-
Sustainability, Free Full-Text20 setembro 2024
-
Agglomeration and driving factors of regional innovation space based on intelligent manufacturing and green economy - ScienceDirect20 setembro 2024
-
Stakeholder perceptions of the value of accounting student organizations - ScienceDirect20 setembro 2024
-
CApp Smart APK for Android Download20 setembro 2024
você pode gostar
-
Netflix: Paw Patrol tiene una fugaz pero genial referencia a JoJo's Bizarre Adventure20 setembro 2024
-
Chad GIFs20 setembro 2024
-
Mortal Kombat 1992 vs 2019 - Fatality Comparison20 setembro 2024
-
Guilty Crown - 06 - Lost in Anime20 setembro 2024
-
Google Maps: esqueleto gigante de cobra é achado e gera polêmica20 setembro 2024
-
No Country for Old Men - Rotten Tomatoes20 setembro 2024
-
Krikor S Mekhitarian on X: Vamo! Começa hoje ao meio-dia, comentários da Flor nos canais do chesscompt @FURIA / X20 setembro 2024
-
7 handpicked Scratch games of Tower defense game20 setembro 2024
-
Memes: Roblox Funny Memes Super Entertaining Funny Memes & Roblox Humor 2019 by Memes20 setembro 2024
-
Sonic the Hedgehog Is Getting a Sequel20 setembro 2024