Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
Por um escritor misterioso
Last updated 10 fevereiro 2025
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://pubs.acs.org/cms/10.1021/acs.jmedchem.7b01854/asset/images/medium/jm-2017-01854x_0009.gif)
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://ars.els-cdn.com/content/image/1-s2.0-S0045206821004818-gr4.jpg)
Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors - ScienceDirect
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://pubs.acs.org/cms/10.1021/acs.jmedchem.7b01854/asset/images/medium/jm-2017-01854x_0004.gif)
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://europepmc.org/articles/PMC6556150/bin/nihms-1029202-f0024.jpg)
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. - Abstract - Europe PMC
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://www.researchgate.net/publication/336996663/figure/fig5/AS:866522222321674@1583606405678/CXCR2-antagonism-up-regulated-the-expression-of-Ki67-Olig2-and-Caspr-expression-in_Q320.jpg)
PDF) CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://patentimages.storage.googleapis.com/1f/9b/b5/2f0f5efade976f/imgf000025_0002.png)
WO2014033122A1 - Inhibitors of cd40-traf6 interaction - Google Patents
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://www.researchgate.net/profile/Mariusz-Papp/publication/51400066/figure/fig5/AS:667848875712518@1536238988284/nfluence-of-S32006-upon-dialysate-levels-of-monoamines-in-the-frontal-cortex-of-freely_Q320.jpg)
PDF) S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://pubs.acs.org/cms/10.1021/acs.jmedchem.7b01854/asset/images/medium/jm-2017-01854x_0008.gif)
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
Chan–Lam Reaction and Lewis Acid Promoted 1,3-Rearrangement of N–O Bonds to Prepare N-(2-Hydroxyaryl)pyridin-2-ones
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://www.tsbiochem.com/content/xtheme/guanwang/images/reg_success.png)
AS 6 陶术生物
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://www.researchgate.net/profile/Mariusz-Papp/publication/51400066/figure/fig7/AS:667848875728905@1536238988331/nfluence-of-S32006-upon-the-reduction-of-sucrose-consumption-elicited-by-chronic-mild_Q320.jpg)
PDF) S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://pubs.acs.org/cms/10.1021/acs.jmedchem.7b01854/asset/images/medium/jm-2017-01854x_0015.gif)
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://ars.els-cdn.com/content/image/1-s2.0-S0223523423009340-gr10.jpg)
Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics - ScienceDirect
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://patentimages.storage.googleapis.com/29/7c/0e/76e009fcdb2d57/imgf000026_0001.png)
WO2014033122A1 - Inhibitors of cd40-traf6 interaction - Google Patents
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://www.ahajournals.org/cms/asset/a73942f6-cde4-4555-a694-2256a71e1a32/35ff1.jpg)
A Potential Role of the CXC Chemokine GROα in Atherosclerosis and Plaque Destabilization
![Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists](https://pubs.acs.org/cms/10.1021/acs.jmedchem.8b00875/asset/images/large/jm-2018-008758_0026.jpeg)
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts
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