How hepatitis C virus evades the immune syste

Researchers from Osaka University unpicked how hepatitis C virus (HCV) and human cytomegalovirus (HCMV) evade the immune system to cause chronic infection. By studying interactions of the HCV core protein and HCMV U2 protein with the host's signal peptide peptidase (SPP), the researchers found that these viral proteins prevent SPP from helping form proteins necessary for a proper immune response. This study may help development of therapies to prevent these viruses from causing chronic infection.

Interfering with interferons: Hepatitis C virus counters innate

Regulation of hepatic innate immunity by hepatitis C virus

Innate and adaptive immune responses in chronic hepatitis B virus

A better understanding of how HIV-1 evades the immune system

Innate and adaptive immune escape mechanisms of hepatitis B virus

Understanding immunity to tackle liver diseases

Now we know hep C's secret strategy to hide from the immune system

Immune responses to HCV and other hepatitis viruses.

Innate and adaptive immune responses in HCV infections - ScienceDirect

B Cell-mediated Humoral Immunity in Chronic Hepatitis B Infection

B 10 – Thomas Krey – SFB 900