Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

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Alzheimer's disease-related dysregulation of mRNA translation

Dissociation of functional and structural plasticity of dendritic spines

Fragile X Mental Retardation Protein Induces Synapse Loss through

Aberrant RNA translation in fragile X syndrome: From FMRP

VCP and ATL1 regulate endoplasmic reticulum and protein synthesis

RNA-Binding Specificity of the Human Fragile X Mental Retardation

Dysregulation and restoration of translational homeostasis in

Frontiers The Coordination of Local Translation, Membranous