Cureus, Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data.

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The Neuropsychological Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Activation Likelihood Estimation Meta-Analysis of Brain Imaging Research

NIMH » Workshop Day 1: Ultrasound Neuromodulation for Mental Health Applications

Cureus

Structural brain abnormalities in borderline personality disorder: A voxel-based morphometry study

Structural brain abnormalities and suicidal behavior in borderline personality disorder. - Abstract - Europe PMC

Frontiers Structural Features Related to Affective Instability Correctly Classify Patients With Borderline Personality Disorder. A Supervised Machine Learning Approach

Frontiers Structural Features Related to Affective Instability Correctly Classify Patients With Borderline Personality Disorder. A Supervised Machine Learning Approach

Why is Borderline Personality Disorder (BPD) misinterpreted as Bipolar Disorder?, by Tabindah Waheed

Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study, BMC Psychiatry

Borderline Schizophrenia: What It Is and More