Development of Adverse Outcome Pathway for PPARγ Antagonism Leading to Pulmonary Fibrosis and Chemical Selection for Its Validation: ToxCast Database and a Deep Learning Artificial Neural Network Model-Based Approach
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Last updated 19 março 2025

Frontiers Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles

Development of AOP relevant to microplastics based on toxicity mechanisms of chemical additives using ToxCast™ and deep learning models combined approach - ScienceDirect

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages - ScienceDirect

Toxics, Free Full-Text

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale, Particle and Fibre Toxicology
Full article: Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework

Toxics, Free Full-Text

Full article: Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment

Adverse outcome pathway (AOP) network for metabolic disorders mediated

Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH - ScienceDirect

Toxics, Free Full-Text

Artificial Intelligence-Based Toxicity Prediction of Environmental Chemicals: Future Directions for Chemical Management Applications

Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro

Integrative Data Mining Approach: Case Study with Adverse Outcome Pathway Network Leading to Pulmonary Fibrosis
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