Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

PDF) Pathogenesis, modulation, and therapy of Alzheimer's disease

PDF] Efficient Investigation and Differential Diagnosis of

Involvement of the Choroid Plexus in the Pathogenesis of Niemann

Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb

PDF] Niemann-Pick Type C Disease—Pathophysiology and Future

Niemann-Pick Disease Concise Medical Knowledge

Finding pathogenic commonalities between Niemann-Pick type C and

PDF) Pharmacological Activation of LXRs Decreases Amyloid-β Levels

PDF) BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick

PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is

IJMS, Free Full-Text

JCM, Free Full-Text

Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb

Niemann–Pick type C disease: cellular pathology and